Amish, Mennonite, and Hutterite
Genetic Disorder Database

Rhizomelic Chondrodysplasia Punctata, type 1

Disorder
OMIM #: #215100  (Click to access OMIM database)
Disorder: Rhizomelic Chondrodysplasia Punctata, type 1 
Also known as: RCDP1
PEROXISOME BIOGENESIS DISORDER 9
PBD9
CHONDRODYSTROPHIA CALCIFICANS PUNCTATA, CDPR 
Clinical
Phenotype: rhizomelia, chondrodysplasia punctata, epiphyseal and metaphyseal abnormalities, coronal clefts of the vertebral bodies, microcephaly, micrognathia, ichthyosis, alopecia, respiratory insufficiency, cataracts, developmental delay, seizures, growth deficiency  
Seen In: Amish
Old Order Mennonite
Old Colony Mennonite
Unknown/Other Mennonite
Hutterite
Remarks: Autosomal recessive 
Mutations
1   Unknown / Other Mennonite  
Gene: PEX7
Base Change:
Amino Acid Change:
Last updated: 2023-02-02 

References
Wardinsky TD, Pagon RA, Powell BR, McGillivray B, Stephan M, Zonana J, Moser A. (1990) Rhizomelic chondrodysplasia punctata and survival beyond one year: a review of the literature and five case reports. Clin Genet Aug;38(2):84-93.
PubMed ID: 2208770 
White AL, Modaff P, Holland-Morris F, Pauli RM. (2003) Natural history of rhizomelic chondrodysplasia punctata. Am J Med Genet A 118A(4):332-42.
PubMed ID: 12687664 

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