Amish, Mennonite, and Hutterite
Genetic Disorder Database

Apert syndrome

Disorder
OMIM #: #101200  (Click to access OMIM database)
Disorder: Apert syndrome 
Also known as: ACROCEPHALOSYNDACTYLY, TYPE I
ACS1 ACS I  
Clinical
Phenotype: craniosynostosis, acrobrachycephaly, megalencephaly, midface hypoplasia, prognathism, hyperteorism, proptosis, strabismus, low nasal bridge, choanal atresia, cleft palate, syndactyly, ventricular septal defect, pyloric stenosis, cryptorchidism, vaginal atresia, fusion of carpal bones, developmental delay, genesis of the corpus callosum, hydrocephalus, ventriculomegaly 
Seen In: Amish
Old Order Mennonite
Old Colony Mennonite
Unknown/Other Mennonite
Hutterite
Remarks: Autosomal dominant 
Mutations
1   Amish  
Gene: FGFR2
Base Change: C>G, at nucleotide 758
Amino Acid Change:
Last updated: 2022-11-01 

References
Personal communication; seen at CSC.  

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