Amish, Mennonite, and Hutterite
Genetic Disorder Database

Diarrhea 6

Disorder
OMIM #: #614616  (Click to access OMIM database)
Disorder: Diarrhea 6 
Also known as: DIAR6
 
Clinical
Phenotype: chronic diarrhea, abdominal bloating, bowel dilatation, other various gastrointestinal issues 
Seen In: Amish
Old Order Mennonite
Old Colony Mennonite
Unknown/Other Mennonite
Hutterite
Remarks: Autosomal dominant 
Mutations
1   Old Order Mennonite  
Gene: GUCY2C
Base Change: A>T, at nucleotide 2381
Amino Acid Change: asp 794 --> val
Last updated: 2022-11-03 

References
Wolfe RM, Mohsen AW, Walsh Vockley C, Bertrand CA, Nicholls RD, Heiman P, Seibold LM, Vockley J, Ghaloul-Gonzalez L. (2021) Novel GUCY2C variant causing familial diarrhea in a Mennonite kindred and a potential therapeutic approach. Am J Med Genet A Jul;185(7):2046-2055.
PubMed ID: 33949097 

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