Amish, Mennonite, and Hutterite
Genetic Disorder Database

Glycogen storage disease Ia

Disorder
OMIM #: #232200  (Click to access OMIM database)
Disorder: Glycogen storage disease Ia 
Also known as: GSD1A
Von Gierke Disease
Hepatorenal form of glycogen storage disease
glucose-6-phosphatase deficiency
hepatorenal glycogenosis 
Clinical
Phenotype: hypoglycemia, hepatomegaly, growth deficiency, motor delay, renal hyperfiltration 
Seen In: Amish
Old Order Mennonite
Old Colony Mennonite
Unknown/Other Mennonite
Hutterite
Remarks: Autosomal recessive 
Mutations
1   Amish  
Gene: G6PC
Base Change: C>T, at nucleotide 1039
Amino Acid Change: gln 347 --> term
Last updated: 2022-12-07 

References
Scott EM, Wenger OK, Robinson E, Colling K, Brown MF, Hershberger J, Radhakrishnan K. (2022) Glycogen storage disease type 1a in the Ohio Amish. JIMD Jun 21;63(5):453-461.
PubMed ID: 36101819 

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