Amish, Mennonite, and Hutterite
Genetic Disorder Database

Periodic Fever, Familial

Disorder
OMIM #: #142680  (Click to access OMIM database)
Disorder: Periodic Fever, Familial 
Also known as: FPF, HIBERNIAN FEVER, FAMILIAL
FHF, FAMILIAL HIBERNIAN FEVER, TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PERIODIC SYNDROME
TRAPS, TNF RECEPTOR-ASSOCIATED PERIODIC SYNDROME 
Clinical
Phenotype: Events occur, on average, every 6 weeks and usually last over a week: abdominal pain, fever, arthralgia, migratory dermatitis, myalgias 
Seen In: Amish
Old Order Mennonite
Old Colony Mennonite
Unknown/Other Mennonite
Hutterite
Remarks:  
Mutations
1   Old Order Mennonite  
Gene: TNFRSF1A
Base Change: G>A, at nucleotide 362
Amino Acid Change: arg 121 --> gln
Last updated: 2010-07-22 

References
Strauss KA, Puffenberger EG. (2009) Genetics, medicine, and the Plain people. Annu Rev Genomics Hum Genet 10:513-36.
PubMed ID: 19630565 

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